Protein S Deficiency Symptoms Pregnancy

Protein c deficiency occurs when a person is unable to produce strong enough protein c or do not have enough of the protein in their body. The mechanism of protein s has been one of the least understood amongst the vitamin k dependent coagulation proteins but it has a central role in the regulation of coagulation a deficiency of protein s predisposes to recurrent venous thromboembolism and fetal loss 2 3. This deficiency upsets the balance in the bloodstream.

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Symptoms of the following disorders can be similar to those of protein s deficiency.

Protein s deficiency symptoms pregnancy. Individuals with mild protein s deficiency are at risk of a type of clot called a deep vein thrombosis dvt that occurs in the deep veins of the arms or legs. The risk to have a child to a parent who has one abnormal protein s gene is 50 with each pregnancy. Protein deficiency can affect almost all aspects of body function. Protein s deficiency is usually hereditary but may be acquired.

Protein s is a vitamin k dependent anticoagulant protein. Women with protein c deficiency have a higher risk of developing clots both during and after pregnancy. If a dvt travels through the bloodstream and lodges in the lungs it can cause a life. The hereditary form of protein s deficiency is caused by a mutation in a gene called pros1.

Some of these symptoms may start to occur even when protein deficiency is marginal. For women with no prior history of vte and protein s deficiency plus any other thrombophilic defect active prophylaxis with lmwh should be given during pregnancy and for 6 weeks postpartum. Protein s deficiency is a rare genetic disorder of blood coagulation that is caused by a variation in the pros1 gene. This condition is inherited in an autosomal dominant manner which means that an individual who inherits only one mutated copy of pros1 has an increased chance of developing symptoms of this disease.

People with this condition have an increased risk of developing abnormal blood clots. Protein s deficiency is a disorder of blood clotting. That s because pregnancy is a risk factor for developing blood clots. As a result it is associated with many symptoms.